Ameliorative effects of autophagy inducer, simvastatin on alcohol ‐induced liver disease in a rat model

1.Alcoholic liver disease is a worldwide public health issue; however, no available treatment is effective up till now. 2.Increasing number of studies has investigated the pleiotropic effects of statins, mainly its autophagy inducer effect. 3.We aimed to monitor the influence of simvastatin on alcohol ‐induced liver injury and elucidate the underlying mechanisms of its cytoprotective effect. AbstractAlcoholic liver disease (ALD) encompasses a variety of liver injuries with various underlying mechanisms but still no effective treatment. So we aimed to monitor the influence of simvastatin on alcohol ‐induced liver injury and elucidate the underlying mechanisms of its cytoprotective effect. Thirty male albino rats were randomly divided into five equal groups. Group 1 (control): received a standard diet; group 2: received simvastatin (10 mg kg−1 day−1) once a day orally for 8 weeks; group 3: received 20% ethanol (7.9  g kg−1 day−1) daily orally for 8 weeks; group 4: received 20% ethanol along with same simvastatin dose daily for 8 weeks; group 5: received 20% ethanol orally for 8 weeks then received the same simvastatin dose for the next 8 weeks. Serum alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, high ‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol were measured. Liver tissue malondialdehyde, reduced glutathione levels, and superoxide dismutase activity were estimated. B‐cell lympho...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research