miR ‐129‐5p and ‐3p co‐target WWP1 to suppress gastric cancer proliferation and migration

Gastric cancer (GC) is a worldwide health problem. Here we identified a novel miR ‐129‐5p/‐3p‐WW domain‐containing E3 ubiquitin protein ligase 1 (WWP1) regulatory axis in GC. Both miR‐129‐5p/‐3p can target WWP1 to suppress GC progression. AbstractGastric cancer (GC) is a worldwide health problem. Uncovering the underlining molecular mechanisms of GC is of vital significance. Here, we identified a novel oncogene WW domain ‐containing E3 ubiquitin protein ligase 1 (WWP1) in GC. WWP1 could promote GC cell proliferation and migration in vitro and expedite GC growth in vivo. We also found out two microRNAs (miRNAs): miR‐129‐5p and ‐3p could both target WWP1. Interestingly, miR‐129‐5p bound to the CDS region o f WWP1 mRNA. The miR‐129 pairs (miR‐129‐5p and ‐3p) play pivotal roles in GC to suppress its proliferation and migration in vitro and slow down GC growth in vivo by repressing WWP1. In summary, we identified two tumor suppressive miRNAs which share the same precursor that could regulate the same oncogene WWP1 in GC. Our finding would add new route for GC research and treatment.

Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Xiaorui Chen, Chang Li, Rongjie Cheng, Zhuo Gao, Xiangbo Meng, Chen Sun, Chenxi Liang, Lianjun Ma, Yanqing Liu Tags: RESEARCH ARTICLE Source Type: research