Short- and long-term alterations of FKBP5-GR and specific microRNAs in the prefrontal cortex and hippocampus of male rats induced by adolescent stress contribute to depression susceptibility

Depression is a highly prevalent mood disorder with different population risks. Exposure to early life adversities is considered a major risk factor for the onset and development of affective disorders (Heim and Binder, 2012; Heim and Nemeroff, 2001). In particular, adolescence is a critical window of brain development; during this stage, the brain is sensitive to stress reactivity, which heightens vulnerability to psychiatric disorders later in life (Lo Iacono and Carola, 2017; Yohn and Blendy, 2017).

Source: Psychoneuroendocrinology - November 11, 2018 Category: Psychiatry Authors: Jingjing Xu, Rui Wang, Yuan Liu, Wei Wang, Dexiang Liu, Hong Jiang, Fang Pan Source Type: research