Hypoperfusion ratio predicts infarct growth during transfer for thrombectomy
We hypothesized that automated assessment of collaterals on computed tomography perfusion can predict the rate of infarct growth during transfer from a primary to a comprehensive stroke center for endovascular stroke treatment. We identified consecutive patients (N = 28) and assessed their collaterals based on the hypoperfusion intensity ratio (HIR) prior to transfer. Infarct growth rate was strongly correlated with HIR (r = 0.78,p < 0.001). Receiver operating characteristic analysis identified HIR ≥ 0.5 as optimal for predicting infarct growth. Patients with HIR ≥ 0.5 had a median infarct growth rate of 10.1ml/h (interquartile range [IQR] = 6.4–18.4) compared with 0.9ml/h (IQR = 0–2.8;p < 0.001) in patients with HIR < 0.5. Patients with HIR ≥ 0.5 had an 83% probability of significant core growth, whereas patients with HIR < 0.5 had an 88% probability of core stability. These preliminary data have the potential to guide decision making regarding whether repeat brain imaging should be performed after transfer to a comprehensive stroke center. Ann Neurol 2018;84:616–620
Source: Annals of Neurology - Category: Neurology Authors: Adrien Guenego,
Michael Mlynash,
Soren Christensen,
Stephanie Kemp,
Jeremy J. Heit,
Maarten G. Lansberg,
Gregory W. Albers Tags: Brief Communication Source Type: research