Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

The objective of this study was to demonstrate a pathophysiological association of pallidal and thalamic local field potentials (LFPs) with TS.MethodsNine medication ‐refractory TS patients were included in the study. Intracerebral LFPs were recorded simultaneously from bilateral pallidal and thalamic DBS electrodes. Spectral and temporal dynamics of pallidal and thalamic oscillations were characterized and correlated with preoperative Yale Global Tic Severity Scale (YGTSS) scores.ResultsPeaks of activity in the theta (3 –12Hz) and beta (13–35Hz) were present in pallidal and thalamic recordings from all patients (3 women/6 men; mean age, 29.8 years) and coupled through coherence across targets. Presence of prolonged theta bursts in both targets was associated with preoperative motor tic severity. Total preoperat ive YGTSS scores (mean, 38.1) were correlated with pallidal and thalamic LFP activity using multivariable linear regression (R² = 0.96;p = 0.02).InterpretationOur findings suggest that pallidothalamic oscillations may be implicated in the pathophysiology of TS. Furthermore, our results highlight the utility of multisite and ‐spectral oscillatory features in severely affected patients for future identification and clinical use of oscillatory physiomarkers for adaptive stimulation in TS. Ann Neurol 2018;84:505–514

Source: Annals of Neurology - October 16, 2018 Category: Neurology Authors: Wolf ‐Julian Neumann, Julius Huebl, Christof Brücke, Roxanne Lofredi, Andreas Horn, Assel Saryyeva, Kirsten Müller‐Vahl, Joachim K. Krauss, Andrea A. Kühn Tags: Research Article Source Type: research