Association between carotid atheroma and cerebral cortex structure at age 73 years

ObjectiveTo examine the relationship between carotid atherosclerosis and cerebral cortical thickness and investigate whether cortical thickness mediates the association between carotid atheroma and relative cognitive decline.MethodsWe assessed 554 community ‐dwelling subjects (male/female: 296/258) from the Lothian Birth Cohort 1936 who underwent brain magnetic resonance imaging and carotid Doppler ultrasound studies at age 73 years. The relationship between carotid atherosclerosis markers (internal carotid artery stenosis, intima–media thickness, velocity, pulsatility, and resistivity indexes) and vertex‐wide cerebral cortical thickness was examined cross‐sectionally, controlling for gender, extensive vascular risk factors (VRFs), and intelligence quotient at age 11 (IQ‐11). We also determined the association between carotid stenosis a nd a composite measure of fluid intelligence at age 73 years. A mediation model was applied to examine whether cortical thickness mediated the relationship between carotid stenosis and cognitive function.ResultsA widespread negative association was identified between carotid stenosis (median  = 15%) and cerebral cortical thickness at age 73 years, independent of the side of carotid stenosis, other carotid measures, VRFs, and IQ‐11. This association increased in an almost dose–response relationship from mild to severe degrees of carotid stenosis, across the anterior and posterior circulation territories. A negative association...
Source: Annals of Neurology - Category: Neurology Authors: Tags: Research Article Source Type: research