Outcome of cell suspension allografts in a patient with Huntington's disease
For patients with incurable neurodegenerative disorders such as Huntington's (HD) and Parkinson's disease, cell transplantation has been explored as a potential treatment option. Here, we present the first clinicopathological study of a patient with HD in receipt of cell ‐suspension striatal allografts who took part in the NEST‐UK multicenter clinical transplantation trial. Using various immunohistochemical techniques, we found a discrepancy in the survival of grafted projection neurons with respect to grafted interneurons as well as major ongoing inflammatory a nd immune responses to the grafted tissue with evidence of mutant huntingtin aggregates within the transplant area. Our results indicate that grafts can survive more than a decade post‐transplantation, but show compromised survival with inflammation and mutant protein being observed within the tra nsplant site. Ann Neurol 2018; 1–7
Source: Annals of Neurology - Category: Neurology Authors: Alexander Maxan,
Sarah Mason,
Martine Saint ‐Pierre,
Emma Smith,
Aileen Ho,
Timothy Harrower,
Colin Watts,
Yen Tai,
Nicola Pavese,
Julie C. Savage,
Marie‐Ève Tremblay,
Peter Gould,
Anne E. Rosser,
Stephen B. Dunnett,
Paola Piccini,
Rog Tags: Brief Communication Source Type: research
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