Prognostic value of JAK2V617F mutation in pseudotumor cerebri associated with cerebral venous sinus thrombosis

ConclusionsPseudotumor cerebri resulting from CSVT in our patients with JAK2V617F mutation was frequent in young patients and needed medical and surgical treatment, without improvement in visual functions and in third caused poor visual outcome. Therefore, we believe that a screening test for JAK2V617F mutation should be considered for patients with CVST without known risk factor presenting with PTC, especially when sagittal sinus or sigmoid sinus involvement or thrombocytosis or high hemoglobin are found upon presentation. This might lead to more aggressive management which may improve the visual prognosis of those young patients.

Source: Acta Neurologica Scandinavica - October 11, 2018 Category: Neurology Authors: Ofira Zloto, Aharon Lubetsky, Iris Ben ‐Bassat Mizrachi, Anat Kesler, Peter A. Quiros, Ruth Huna‐Baron Tags: ORIGINAL ARTICLE Source Type: research