Single antiepileptic drug levels do not predict adherence and nonadherence

Conclusions“Subtherapeutic” AED plasma levels only rarely are caused by nonadherence whereas levels in the “therapeutic range” by no means prove that the patient is adherent to treatment. For meaningful interpretation, any level needs to be compared with other levels of the same patient. Our findings s trongly emphasize the principle of individualized therapeutic AED monitoring as promoted by the Therapeutic Strategies Commission of the ILAE.

Source: Acta Neurologica Scandinavica - October 11, 2018 Category: Neurology Authors: Mariana Lunardi, Katia Lin, Roger Walz, Peter Wolf Tags: CLINICAL COMMENTARY Source Type: research