Chronic liver injury drives non ‐traditional intrahepatic fibrin(ogen) cross‐linking via tissue transglutaminase

ConclusionsThese results indicate that neither traditional fibrin clots, formed by the thrombin:FXIIIa pathway, nor atypical TGM2 ‐cross‐linked fibrin(ogen) contribute to experimental CCl4‐induced liver fibrosis. Collectively, the results indicate that liver fibrosis occurs independently of intrahepatic fibrin(ogen) deposition.This article is protected by copyright. All rights reserved.

Source: Journal of Thrombosis and Haemostasis - November 11, 2018 Category: Hematology Authors: L.G. Poole, A. Pant, K.S. Baker, A.K. Kopec, H.M. Cline ‐Fedewa, S.E. Iismaa, M.J. Flick, J.P. Luyendyk Tags: Original Article ‐ Coagulation Source Type: research