Cutaneous adverse drug reactions to psychotropic drugs and their risk factors – a case-control study

Although the true incidence of adverse drug reactions (ADRs) is difficult to determine, there is evidence that cutaneous adverse drug reactions (CADRs) are among the most frequently observed adverse reactions to drugs (Svensson et al., 2001). CADRs account for 10 –20% of all reported ADRs (Faich et al., 1987; van der Linden et al., 1998). These reactions may range from mildly discomforting exanthematous skin rashes to severe, life-threatening event like toxic epidermal necrolysis (TEN). The most severe and life-threatening types of CADRs consist of erythem a multiforme, urticaria, drug-induced hypersensitivity syndrome (DIHS) also referred to as drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis - including Stevens-Johnson syndrome (SJS) and TEN (Mitkov et al., 2014).

Source: European Neuropsychopharmacology - November 10, 2018 Category: Psychiatry & Psychology Authors: Waldemar Greil, Xueqiong Zhang, Hans Stassen, Renate Grohmann, Ren é Bridler, Gregor Hasler, Sermin Toto, Stefan Bleich, Siegfried Kasper Source Type: research