Anti-persister activity of squalamine against Acinetobacter baumannii
Acinetobacter baumannii is a nosocomial pathogen responsible for many infections usually localized on skin and in urinary or respiratory tracts. The emergence of multi-drug resistance in this bacterium obviously complicates the treatment efficiency.1 However, the resistant character of A. baumannii is not the sole cause of therapeutic failure. Indeed, dormant cells, i.e. persisters and Viable But Non Culturable cells (VBNCs), are known to survive to high amounts of antimicrobials, and play an important role in the infection relapse and chronic diseases.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Marion Nicol, Mohamed Amine Ben Mlouka, Thierry Berthe, Patrick Di Martino, Thierry Jouenne, Jean-Michel Brunel, Emmanuelle D é Tags: Short Communication Source Type: research