Endometrial stromal sarcoma occurring 20 years after total hysterectomy for myomas

Publication date: February 2014 Source:Gynecology and Minimally Invasive Therapy, Volume 3, Issue 1 Author(s): Yen-Feng Lu , Ben-Shian Huang , Chiung-Ru Lai , Kuan-Chin Wang , Ming-Shyen Yen , Peng-Hui Wang Extrauterine and extraovarian endometrial stromal sarcomas (ESSs) without endometriosis are extremely rare. A 57-year-old woman had a pelvic mass. Twenty years previously, she had undergone total hysterectomy and left salpingo-oophorectomy for uterine myomas. A series of examinations, including upper and lower gastrointestinal evaluations, and tumor markers such as cancer antigen (CA)-125, CA 19-9, and carcinoembryonic antigen were all unremarkable; however, an 18-cm heterogeneous mass with strong enhancement and many surrounding engorged vessels was present in the pelvic computed tomography image. Exploratory laparotomy showed a 20-cm gray firm mass. A complete tumor excision was performed. Microscopic features showed abundant spindle cells and epithelioid-like cells with increased cellularity. Immunohistochemistry was strongly positive for CD10, FLI-1, and vimentin; weakly positive for estrogen and progesterone receptors; and negative for CD117, CD34, HMB45, alpha-inhibin, SMA, and S-100. This favored the diagnosis of ESS. The right ovary and fallopian tube, omentum, and pelvic lymph nodes were unremarkable. The patient was treated with 2-year hormone therapy (oral megestrol, 160 mg, taken daily) and radiation therapy (50.4 Gy, separated by 28 fractions). She...
Source: Gynecology and Minimally Invasive Therapy - Category: OBGYN Source Type: research