Genetic barrier and variant fitness in hepatitis C as critical parameters for drug resistance development

This article illustrates the basic mechanisms underlying development of resistance to specific antiviral agents with a special emphasis on NS3 protease inhibitors. The role of fitness deficits and compensation for variant selection and persistence is discussed together with technical issues in sequencing as well as clinical implications in the use of DAAs now and in the future.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research