Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal inverted papilloma to squamous cell carcinoma

In conclusion, our results suggest that a small subset of these tumours c ould be related to HPV infection;EGFR mutations characterise those ISPs with a lower risk of developing into SCC; LINE ‐1 hypomethylation is associated with occupational exposure and could identify more aggressive nasal SCC.This article is protected by copyright. All rights reserved.

Source: International Journal of Cancer - November 9, 2018 Category: Cancer & Oncology Authors: Nora Sahnane, Giorgia Ottini, Mario Turri ‐Zanoni, Daniela Furlan, Paolo Battaglia, Apostolos Karligkiotis, Chiara Albeni, Roberta Cerutti, Eleonora Mura, Anna Maria Chiaravalli, Paolo Castelnuovo, Fausto Sessa, Carla Facco Tags: Research Article Source Type: research