Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group

CONCLUSIONSCompared with males without chromosomal abnormalities, males with KS are more likely to be diagnosed with a mediastinal GCT. The presence of KS should be considered in males with a diagnosis of mediastinal GCT. In the current study, the authors report that approximately one ‐third of males with mediastinal germ cell tumors have Klinefelter syndrome, and therefore screening of these individuals for the syndrome may be warranted. Males with Klinefelter syndrome are 19 times as likely as males without Klinefelter syndrome to develop germ cell tumors.

Source: Cancer - November 9, 2018 Category: Cancer & Oncology Authors: Lindsay A. Williams, Nathan Pankratz, John Lane, Mark Krailo, Michelle Roesler, Michaela Richardson, A. Lindsay Frazier, James F. Amatruda, Jenny N. Poynter Tags: Original Article Source Type: research