LRRK2 impairs autophagy by mediating phosphorylation of leucyl ‐tRNA synthetase
In this study, we elucidated that leucyl‐tRNA synthetase (LRS) was an LRRK2 kinase substrate and identified T293 as an LRRK 2 phosphorylation site. LRRK2‐meidated LRS phosphorylation or G2019S can lead to impairment of LRS editing, increased ER stress, and accumulation of autophagy markers. These results demonstrate that LRRK2 kinase activity can facilitate accumulation of misfolded protein, suggesting that LRRK2 kinas e might be a potential PD therapeutic target along with previous studies.
Source: Cell Biochemistry and Function - Category: Biochemistry Authors: Dong Hwan Ho,
Hyejung Kim,
Daleum Nam,
Hyuna Sim,
Janghwan Kim,
Hyung Gun Kim,
Ilhong Son,
Wongi Seol Tags: RESEARCH ARTICLE Source Type: research