Anti-inflammatory effects of cellulose nanofiber made from pear in inflammatory bowel disease model

Publication date: January 2014 Source:Bioactive Carbohydrates and Dietary Fibre, Volume 3, Issue 1 Author(s): Kazuo Azuma , Tomohiro Osaki , Shinsuke Ifuku , Hiroyuki Saimoto , Minoru Morimoto , Osamu Takashima , Takeshi Tsuka , Tomohiro Imagawa , Yoshiharu Okamoto , Saburo Minami The aim of this study was to evaluate the effects of cellulose nanofibers from Japanese pear (P-CNF) on acute IBD by using a mouse model of this disorder. Furthermore, using this mouse model, we compared the effects between P-CNF and cellulose nanofibers from wood (W-CNF). P-CNF suppressed shortening of the colon length and improved the histological tissue injury in the mice. It also suppressed the activation of nuclear factor-kappa B and fibrosis of the colon, as well as the myeloperoxidase activation of inflammatory cells such as leukocytes. On the other hand, W-CNF did not improve the histological tissue injury, or suppress shortening of the colon length, colon inflammation, and fibrosis in the mice. These results revealed that P-CNF has anti-inflammatory effects in the experimental IBD mouse model. Our results indicate that P-CNF could be a potential source of new dietary fiber for patients with IBD.

Source: Bioactive Carbohydrates and Dietary Fibre - October 12, 2014 Category: Food Science Source Type: research