Successful long ‐term hematological and immunological reconstitution by autologous cord blood transplantation combined with post‐transplant immunosuppression in two children with severe aplastic anemia

We report the successful treatment of two patients with SAA, aged 15 and 24 months, with autologous cord blood combined with immunosuppression. After conditioning with 200 mg/kg cyclophosphamide and ATG, 7.5 mg/kg, 32.2 × 107/kg, and 3.8  × 107/kg autologous cord blood nucleated cells were infused, respectively. One of our patients underwent transplantation after failure of IST. Both patients received post ‐transplant immunosuppression with cyclosporine for 12 months. They remain disease‐free 6 years post‐transplantation.

Source: Pediatric Transplantation - November 8, 2018 Category: Transplant Surgery Authors: Avgerinou Georgia, Oikonomopoulou Christina, Kaisari Aikaterini, Ioannidou Elda, Komitopoulou Anna, Paisiou Anna, Tourkantoni Natalia, Filippidou Maria, Kattamis Antonios, Vessalas George, Peristeri Ioulia, Goussetis Evgenios, Kitra Vasiliki Tags: CASE REPORT Source Type: research