Renal outcome with eculizumab in two diarrhea-associated hemolytic–uremic syndrome cases with severe neurologic involvement
We report on two STEC-HUS children with severe neurologic involvement treated with eculizumab. Despite prompt resolution of initial neurologic findings upon treatment with eculizumab, proteinuria and hypertension persisted in these patients. The persistence of these two risk factors is particularly emphasized to discuss the long-term effects of eculizumab, especially on renal involvement. ç”¢å¿—è³€æ¯’ç´ å¤§è…¸æ¡¿èŒç›¸é—œæº¶è¡€æ€§å°¿æ¯’症候群 (STEC-HUS) 的目標器官包括腎臟åŠè…¦éƒ¨ï¼Œåœ¨æ‚£è€…體內會出ç¾è£œé«”æ›¿ä»£é€”å¾‘çš„æ´»åŒ–ã€‚æœ‰å ±å‘ŠæŒ‡å‡ºï¼Œå°æ–¼ STEC-HUS 所表ç¾çš„é‡åº¦ç¥žç¶“å¸ä½µç™¼ç—‡ï¼ŒC5 å–®æ ªæŠ—é«” (eculizumab) 具有若干效用。以下兩宗兒童個案,å‡ç‚ºå…¼å…·é‡åº¦ç¥žç¶“å¸ä½µç™¼ç—‡çš„ STEC-HUS,且接å—了 eculizumab 治療。治療期間神經å¸æ–¹é¢å‡ºç¾è¿…速改善,然而ä»æŒçºŒæœ‰è›‹ç™½å°¿åŠé«˜è¡€å£“æƒ…å½¢ï¼Œå› æ¤å¿…é ˆæ³¨æ„ eculizumab 的長期影響特別是腎臟效應。
Source: Hong Kong Journal of Nephrology - Category: Urology & Nephrology Source Type: research
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