Gliosarcoma with extension to infratemporal fossa and ventricle

Publication date: December 2013 Source:Formosan Journal of Surgery, Volume 46, Issue 6 Author(s): Sang-Jek Liew , Wen-Jui Liao , Jung-Tung Liu , Wei-Chean Tan Gliosarcomas are bimorphic intra-axial tumors. They rarely involve both the skull base and ventricles simultaneously. A case of temporal lobe gliosarcoma with significant infratemporal fossa and lateral ventricle extension is reported. The patient, an 82-year-old man, had gradual general weakness and a poor response to speech for 3 weeks. Neurological examination was unremarkable except for poor awareness and myoclonic jerks. Magnetic resonance imaging revealed a 72-cm3 right temporal mass with extension into the infratemporal fossa and the wall of the temporal horn of the lateral ventricle, and consisted of intra-axial and extracranial components with extension to the cavernous sinus, dura, temporal bone, and sphenoid ridge. The patient underwent a right-sided craniotomy through the orbitozygomatic approach. Gross total resection was achieved. The histopathological diagnosis was gliosarcoma. Fractional whole-brain radiation and chemotherapy with temozolomide were administered subsequently. However, the tumor recurred 1.5 months after his initial treatment, and the survival time was 9.2 months. In the case of a mass lesion with both intra-axial and extracranial involvement, the simultaneous involvement of both the skull base and ventricles is highly unexpected, and gliosarcoma should be included in the different...
Source: Formosan Journal of Surgery - Category: Surgery Source Type: research