DAP12/TREM2 Expression by Mouse and Human Liver DC: Functional Implications and Regulation of Liver Ischemia ‐Reperfusion Injury

Conclusions: our data reveal a close association between DAP12 and TREM2 expression by liver DC and suggest that, by negatively regulating liver DC stimulatory function, DAP12 promotes their control of hepatic inflammatory responses. The DAP12/TREM2 signaling complex may represent a novel therapeutic target for control of acute liver injury/liver inflammatory disorders.This article is protected by copyright. All rights reserved.

Source: Hepatology - October 29, 2018 Category: Internal Medicine Authors: Toshimasa Nakao, Yoshihiro Ono, Helong Dai, Ryosuke Nakano, Angelica Perez ‐Gutierrez, Geoffrey Camirand, Hai Huang, David A. Geller, Angus W. Thomson Tags: Liver Biology and Pathobiology Source Type: research