Thrombotic microangiopathy associated with Gemcitabine use: presentation and outcome in a national French retrospective cohort

ConclusionThis large cohort confirms the severity of G ‐TMA, associated with severe renal failure and death. Edema and hypertension could be monitored in patients treated with Gemcitabine to detect early TMA. The benefit of PE or Eculizumab deserves further investigation.

Source: British Journal of Clinical Pharmacology - November 5, 2018 Category: Drugs & Pharmacology Authors: Florence Daviet, Franck Rouby, Pascale Poullin, Julie Moussi ‐Francès, Marion Sallèe, Stéphane Burtey, Julien Mancini, Florence Duffaud, Renaud Sabatier, Bertrand Pourroy, Aurélie Grandvuillemin, Steven Grange, Véronique Frèmeaux‐Bac Tags: ORIGINAL ARTICLE Source Type: research