Time to abandon single-site irradiation for inducing abscopal effects

Time to abandon single-site irradiation for inducing abscopal effectsTime to abandon single-site irradiation for inducing abscopal effects, Published online: 06 November 2018; doi:10.1038/s41571-018-0119-7Many clinical trials are testing the safety and/or efficacy of combining radiotherapy with immunotherapy, nearly all using a single-site irradiation (or ‘abscopal’) approach, but emerging evidence suggests that this approach likely produces suboptimal results. The authors of this Perspective provide a biological rationale supporting the abandonment of the abscopal approach, and instead advocate exploring comprehensive irradiation of multiple/all lesions.
Source: Nature Clinical Practice Oncology - Category: Cancer & Oncology Authors: Source Type: research