Endometrial epithelial cell dynamics during human implantation

Human implantation is multiple step mechanism of cross talk between embryo and endometrial tissue, consisting of apposition, adhesion, penetration, and invasion. These sequential steps are also divided into apposition, adhesion, destruction, and reconstruction for endometrial epithelial cell (EEC) sheet. EEC sheet is physically and immunologically important defense barrier, however, little is known about mechanism except apoptosis for its destruction. Using human cell line (human endometrial adenocarcinoma cell line, Ishikawa for EEC model, and spheroid of human choriocarcinoma cell line, JAR for embryo model), human EEC dynamics was investigated by various assays.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research