Onionin A inhibits epithelial ovarian cancer proliferation by the suppression of STAT3 activation in tumor cells and macrophages

Objective: In epithelial ovarian cancer (EOC), M2 macrophage (Mø), which is one of components forming the cancer microenvironment, is polarized from Mø and plays an important role in cancer cell proliferation via STAT3 pathway. Onionin A (ONA), a natural compound derived from onion, has an inhibitory effect on M2 polarization by STAT3 inactivation. Here we elucidated effects of ONA in EOC via STAT3 inactivation.

Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: J. Nakao, Y. Fujiwara, K. Takaishi, Y. Komohara, H. Tashiro, M. Takeya, H. Katabuchi Tags: Oral free communication abstracts Source Type: research