CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with endometrial cancer

Background: CD169 is expressed on specific macrophages (MΦ) and promotes inflammation through the activation of lymphocytes. In mice, CD169+ MΦ in lymph nodes induce anti-tumor immunity by the presentation of tumor antigen after phagocytosis of dead tumor cells. To detect a factor predicting anti-tumor immunity or prognosis in patients with endometrial cancer (EC), we evaluated the relationship between CD169+ MΦ in regional lymph node (RLN) and clinical outcome in patients with EC.

Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: M. Yamaguchi, K. Ohnishi, Y. Komohara, F. Saito, C. Erdenebaatar, K. Fujimoto, H. Tashiro, M. Takeya, H. Katabuchi Source Type: research