Expression of NCRs and RORγt in peripheral blood NK cells of recurrent pregnancy losses

Objectives: More that half of women with recurrent pregnancy loss (RPL) are diagnosed with unexplained RPL. Some of these women may have immune abnormality such as NK cells. Recently, NK22 cell, that is NKp46+ and produce IL-22 is reported. IL-22 is secreted from Th17 lymphocytes, and retinoid-related orphan receptor γt (RORγt) is used for marker of Th17 lymphocytes. In gut, not only Th17 lymphocytes but also NKp46+ or NKp44+ NK cells, one of the NCRs, produce IL-22. However, the relationship of NK22 and the expression of RORγt in peripheral blood and endometrium is unclear.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research