Autoantibodies to protein s and protein S deficiency in patients with recurrent pregnancy loss

There is now genetic evidence that protein S (PS) participates in a variety of physiological role distinct from hemostasis, including cell proliferation/survival, apoptosis and angiogenesis. Recurrent pregnancy loss (RPL) patients (n=300) were screened for total PS antigen, antibodies to PS (Western blot), antiphospholipid antibodies, factor XII (FXII) activity. Informed consent was obtained from each patient. Among 300 RPL patients, 90 patients (30%) were deficient for total PS antigen (
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research