A case report of neonatal hemochromatosis treated by high-dose intravenous immunoglobulin

Neonatal hemochromatosis (NH) is characterized by serious fetal or neonatal liver failure due to alloimmune liver damage. Specific diagnosis using immunohistochemical staining of membrane attack complex (MAC IHC) in the liver and maternal treatment with high-dose intravenous immunoglobulin (IVIG) have recently become the standard management. Here, we report a successful pregnancy in a woman whose index pregnancy was diagnosed as NH and who was treated with IVIG. A 37-year-old, gravida 1 para 0 woman delivered a normal-appearing neonate who died of liver failure only 17h after delivery in spite of having shown no symptoms during gestation or delivery.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research