Subcellular localization of era and their effects on cell size

Current data support the idea that estrogen receptor alpha (ERα) is located in cell membrane, cytoplasm, and/or nucleus. ERα plays important roles in such processes as cellular proliferation, differentiation, migration and invasion respectively or collectively. In these processes, ERα cross-talk with other factors to control distinctive groups of target genes genetically and epigenetically. While some of these factors appear to regulate the accessibility of promoters, others are members of various kinase cascades such as PI3K-AKT that control crucial cellular events.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research