DR6 is epigenetically involved in the pathogenesis of endometriosis by creating the proliferative and anti-apoptotic characteristics

Objective: Accumulating evidence suggests that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. The goals of this study were to identify the roles of death receptor (DR) 6, the only TNFRSF whose expression is epigenetically repressed in endometriotic cyst stromal cells (ECSCs), in the pathogenesis of endometriosis.

Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: K. Kai, K. Nasu, Y. Aoyagi, Y. Tsukamoto, N. Hijiya, M. Okamoto, M. Moriyama, H. Narahara Source Type: research