Interleukin-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan metabolism in ectopic endomtetrial stromal cells

Objective: Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are enzymes that catalyze the first and rate-limiting step of tryptophan degradation (i.e. from tryptophan to kynurenine) and thereby regulate tryptophan levels. Decrease in tryptophan levels inhibits T cell function and contributes to immune tolerance. While IFNγ increases IDO expression, a molecule that regulates TDO expression remains to be elucidated. We evaluated the effect of IL-1β, a typical endometriosis-associated cytokine, on TDO expression in ectopic endometrial stromal cells (ESCs).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research