T-bet in Tfh cells: Now you see me, now you dont

In this issue, Fang et al. (https://doi.org/10.1084/jem.20180927) report on a subset of T follicular helper (Tfh) cells that transiently expresses T-bet yet continues to produce IFN- at late stages of GC reactions following immunization. They find other genes uniquely expressed in this IFN-–producing Tfh subset, such as NKG2D, that can be used to better distinguish these functionally distinct Tfh cells.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Insights Source Type: research