Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses

One of the current challenges in mental health research is the identification of risk factors and mechanisms related to individual vulnerability to develop psychopathologies (Weger and Sandi, 2018). Given the well-known impact of stress in triggering and exacerbating psychopathologies (de Kloet et al., 2016; McEwen et al., 2012), a great deal of research is concentrating on understanding the role of the major physiological stress systems [i.e., the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenocortical (HPA) axis] in this context (Carnevali et al., 2018; de Kloet et al., 2005; Pruessner et al., 1997; Sgoifo et al., 2015; Walker et al., 2018).

Source: Psychoneuroendocrinology - November 2, 2018 Category: Psychiatry Authors: Damien Huzard, Sriparna Ghosal, Jocelyn Grosse, Luca Carnevali, Andrea Sgoifo, Carmen Sandi Source Type: research