Chemosensitivity is differentially regulated by the SDF-1/CXCR4 and SDF-1/CXCR7 axes in acute lymphoblastic leukemia with MLL gene rearrangements

Rearrangements of the mixed-lineage-leukemia (MLL) gene at chromosome 11q23 are frequently observed in infantile acute lymphoblastic leukemia (ALL) and therapy-related second leukemia [1,2], and ALL with MLL gene rearrangements (MLL+ALL) is refractory to chemotherapy and its prognosis is still dismal although it has been improved to some extent by performing hematopoietic stem cell transplantation [3,4]. Of interest, MLL+ALL has a unique gene profile clearly distinguishable from other types of ALL and acute myeloid leukemia (AML), and specific genes such as Fms-like tyrosine kinase 3 (FLT3), CD44, LMO2, and HOXA9 are overexpressed in MLL+ALL [5].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research