The PER extended-spectrum beta-lactamases originate from Pararheinheimera sp.

Enzymes belonging to the PER family of extended spectrum beta-lactamases (ESBLs) confer resistance to cephalosporins, penicillins and aztreonam, but are inhibited by clavulanic acid, tazobactam and sulbactam [1]. Since the discovery of PER-1 in 1993, seven new variants (PER-2 to PER-8) have been described in the literature. They can be divided into two distinct groups based on their similarity to PER-1. Whereas PER-3, 4, 5, 7 and 8 share 98-99% amino acid identity with PER-1, the amino acid sequences of PER-2 and 6 are only 86% similar to that of PER-1.

Source: International Journal of Antimicrobial Agents - November 2, 2018 Category: Drugs & Pharmacology Authors: Stefan Ebmeyer, Erik Kristiansson, D. G. Joakim Larsson Source Type: research