MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients

ConclusionsVariant rs1801133 was confirmed to have remarkable influence on the MTX-induced toxicity. We recommend identification of the genotype of MTHFR variant prior to the application of high-dose MTX to OS patients, which could be an important predictor to screen severe toxicities and thus improve treatment outcomes.
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research