Dexmedetomidine reduces oxidative stress and provides neuroprotection in a model of traumatic brain injury via the PGC-1 α signaling pathway

In this study, the neuroprotective effect of DEX and its potential mechanism were assessed in a model of TBI. DEX treatment relieved encephala edema and neuron cell apoptosis and increased behavioral function. These protective effects were accompanied by upregulation of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 α) expression.

Source: Neuropeptides - November 1, 2018 Category: Neuroscience Authors: Fayin Li, Xiaodong Wang, Zhikui Deng, Xianlong Zhang, Pengfei Gao, Hailin Liu Source Type: research