Human leukocyte antigen-associated gag and nef polymorphisms in HIV-1 subtype A/E-infected individuals in Vietnam

Publication date: Available online 30 October 2018Source: Microbes and InfectionAuthor(s): Naofumi Takahashi, Saori Matsuoka, Tam Tran Thi Minh, Hien Pham Ba, Taeko K. Naruse, Akinori Kimura, Teiichiro Shiino, Ai Kawana-Tachikawa, Koichi Ishikawa, Tetsuro Matano, Lan Anh Nguyen ThiAbstractNumbers of HLA-associated polymorphisms have been reported on HIV-1 subtypes B and C, but few on other subtypes. Here, we analyzed HLA-associated gag and nef polymorphisms in HIV-1 subtype A/E prevalent in Vietnam. We determined HLA-A, B and C genotypes in 179 HIV-1-infected Vietnamese by next generation sequencing and analyzed proviral genome sequences in 144 of them, showing that 142 of the 144 were subtype A/E. Analysis revealed HLA-associated subtype A/E gag and nef polymorphisms at nineteen residues including those newly determined. Accumulation of these data would contribute to our understanding of HIV-1 subtype A/E and host immune interaction.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research