S100B Protein Value in Predicting Brain Death After Head Trauma

Background: Protein S100B is a biomarker that reflects brain injury after trauma. In traumatic brain injury definite prediction of outcome of the patients is an important goal. In this regard, our study focuses on the S100B protein value in predicting brain death after head trauma. Methods: Seventy-two patients with a mean age of 40±17.72 years (range, 5 to 80 y; 50 male and 22 female) with severe head trauma [Glasgow Coma Scale (GCS)≤8] were recruited in this cross-sectional study. For all patients, the GCS score was evaluated, computed tomography scan was performed, and a single 5 mL blood sample was obtained from each patient at 3 time points (on admission, 48 h later, and a week later or after brain death) to determine the level of S100B protein. Results: The primary and last GCS of patients had a predictive value in determining brain death (P
Source: Neurosurgery Quarterly - Category: Neurosurgery Tags: Original Articles Source Type: research