Methylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndrome

Because acute coronary syndrome (ACS) is a leading cause of death, increased effort has been made toward improving its treatment outcomes and prognosis (Benjamin et al., 2018). Depression is a common comorbidity in ACS patients and is associated with poor prognoses with increased morbidity and mortality (Lichtman et al., 2014). These phenomena may be due to common biological mechanisms shared by ACS and depression. Because depression can be treated, a clearer understanding of the pathophysiology of depression in ACS patients could improve its prognosis.

Source: Psychoneuroendocrinology - October 29, 2018 Category: Psychiatry Authors: Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Hye-Ran Kim, Myung-Geun Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin-Sang Yoon, Jae-Min Kim Source Type: research