Concern regarding the publication by Posbergh et al. “A nonsynonymous change in adhesion G protein-coupled receptor L3 associated with risk for equine degenerative myeloencephalopathy in the Caspian horse”, J Equine Vet Sci 2018;70:96-100

Posbergh et al. (2018) reported on the analysis of equine degenerative myeloencephalopathy in Caspian horses [1]. The authors hypothesized a monogenic autosomal recessive inheritance for this trait. Only two cases were used for the analysis. The cases represented paternal half-siblings and were described as a Caspian and a Caspian cross. The dams were not clearly identified in the publication. However, the authors mention a Shetland Pony, which had an affected offspring. If the Shetland Pony indeed was the dam of one of the two cases of the publication, this would argue against autozygosity in the cases.
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research