Fibroblast growth factor receptors as treatment targets in clinical oncology

Fibroblast growth factor receptors as treatment targets in clinical oncologyFibroblast growth factor receptors as treatment targets in clinical oncology, Published online: 26 October 2018; doi:10.1038/s41571-018-0115-yFGFR alterations can be detected in a small subset of many different cancer types. Inspired by the successes with other targeted therapies, preliminary attempts to target FGFR-altered cancers have been hampered by low response rates and acquired resistance. In this Review, the author describes the development of FGFR inhibitors thus far, and provides guidance on future research priorities.
Source: Nature Clinical Practice Oncology - Category: Cancer & Oncology Authors: Source Type: research