Joint registration and synthesis using a probabilistic model for alignment of MRI and histological sections

Histology is the study of tissue microanatomy. Histological analysis involves cutting a wax-embedded or frozen block of tissue into very thin sections (in the order of 10 microns), which are subsequently stained, mounted on glass slides, and examined under the microscope. Using different types of stains, different microscopic structures can be enhanced and studied. Moreover, mounted sections can be digitised at high resolution – in the order of a micron. Digital histological sections not only enable digital pathology in a clinical setting, but also open the door to an array of image analysis applications.

Source: Medical Image Analysis - September 22, 2018 Category: Radiology Authors: Juan Eugenio Iglesias, Marc Modat, Lo ïc Peter, Allison Stevens, Roberto Annunziata, Tom Vercauteren, Ed Lein, Bruce Fischl, Sebastien Ourselin, for the Alzheimer’s Disease Neuroimaging Initiative Source Type: research