Outcomes of Fosfomycin Use in Ceftriaxone-Resistant Enterobacteriaceae Urinary Tract Infection in the Elderly

Fosfomycin is a cell-wall active antibiotic with bactericidal activity against many gram-positive and negative bacteria. One dose of 3g oral Fosfomycin is indicated for uncomplicated cystitis in females [1]. Increasingly, it is used to treat cystitis caused by drug-resistant organisms but data on patients with renal impairment are lacking. We conducted a retrospective study to determine the safety and efficacy of fosfomycin in treating cystitis caused by extended spectrum beta-lactamase (ESBL) Enterobacteriaceae in a 1400-bed teaching hospital.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research