Olive Fruit (Olea Europaea L.): Chemopreventive Effect in the Rat Model of Hepatocellular Carcinoma

Publication date: Available online 24 October 2018Source: PharmaNutritionAuthor(s): Farshad H. Shirazi, Mehrdad Piri, Shima Keshavarz, Saman Gholami, Seyed Hojjat Hosseini, Maryam Noubarani, Sina Andalib, Mohammad Kamalinejad, Hasan Adiban, Mohammad Reza EskandariAbstractPrimary liver cancer or hepatocellular carcinoma (HCC) is an aggressive tumor with poor prognosis. Olea europaea L. commonly called olive contains diverse phytochemical constituents that have preventive effects against different diseases. The purpose of this investigation was to study the chemopreventive effect of aqueous extract of Olea europaea L. (AOE) against diethylnitrosamine (DEN)-induced HCC in rats. Olive-treated rats were pretreated with AOE intragastrically at three different doses two weeks prior to DEN injection that continued until 8 weeks. At three different time points, blood samples were collected for biochemical analysis. In the present investigation, a significant decrease in serum biomarkers of liver damage and cancer, including alfa-fetoprotein (AFP), gamma glutamyl transpeptidase (GGT), alanine transaminase (ALT), and aspartate transaminase (AST) were observed in AOE supplemented animals when compared to DEN-treated rats. In addition, AOE counteracted DEN-induced hepatic oxidative stress in rats illustrated by the restoration of reduced glutathione (GSH) and the reduction of lipid peroxidation in HCC rats. Furthermore, AOE prevented increase of relative liver weight as a prognostic marke...
Source: PharmaNutrition - Category: Nutrition Source Type: research