Commensal lactic acid-producing bacteria affect host cellular lipid metabolism through various cellular metabolic pathways: Role of mTOR, FOXO1, and autophagy machinery system

ConclusionLAPB prevent high- fat diet/endotoxin/inflammation-mediated disruption of normal cellular lipid metabolism by inhibiting mTOR/FOXO1/NF-kB activity and enhancing the occurrence of autophagy. This may be a molecular basis by which LAPB enhance intrinsic cellular tolerance against excess calorie consumption and participate in homeostatic regulation of metabolic processes in vivo.Graphical abstract
Source: PharmaNutrition - Category: Nutrition Source Type: research