Hyperprogressive disease: recognizing a novel pattern to improve patient management

Hyperprogressive disease: recognizing a novel pattern to improve patient managementHyperprogressive disease: recognizing a novel pattern to improve patient management, Published online: 25 October 2018; doi:10.1038/s41571-018-0111-2A deterioration of disease can occur upon treatment with anti-PD-1/PD-L1 monoclonal antibodies; this paradoxical phenomenon is defined as hyperprogression. The authors discuss the pathophysiological hypotheses that might explain hyperprogressive disease and the resulting challenges for patient management, with a focus in clinical decisions involving immune-checkpoint inhibitors.

Source: Nature Clinical Practice Oncology - October 25, 2018 Category: Cancer & Oncology Authors: St éphane Champiat Roberto Ferrara Christophe Massard Benjamin Besse Aur élien Marabelle Jean-Charles Soria Charles Fert é Source Type: research