The expression profile of p14, p53 and p21 in tumour cells is associated with disease-specific survival and the outcome of postoperative chemotherapy treatment in muscle-invasive bladder cancer

Patients with muscle-invasive urinary bladder cancer (MIBC) treated with cystectomy have a high risk of recurrence and cancer-related death despite aggressive treatment. Recurrence-free survival after radical cystectomy (RC) and lymph node (LN) dissection at five years ranges from 58% to 62% [1,2]. Clinical and pathological variables such as T-category, tumour grade, lymphovascular invasion (LVI), and number of LN metastases are used as prognostic indicators in assessment of patients with urinary bladder cancer (UBC) [3 –5].
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Original article Source Type: research